Endocrine Abstracts

Alterations in insulin/insulin-like growth factor 1 signalling (IIS) play a key role in lifespan extension in model organisms. For example, mice globally null for insulin receptor substrate protein 1 (IRS1), a major intracellular IIS effector, are both long-lived and have improved health during this long life. However, unlike long-lived GH dwarf mice and dietary restricted (DR) mice, Irs1 null mice combine an increased lifespan with lifelong insulin resistance. These findings ...